4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
CAS: 877636-42-5
Molecular Formula: C17H11N3O6S
4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]- - Names and Identifiers
4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]- - Physico-chemical Properties
| Molecular Formula | C17H11N3O6S |
| Molar Mass | 385.35 |
| Density | 1.54±0.1 g/cm3(Predicted) |
| Boling Point | 624.1±55.0 °C(Predicted) |
| Solubility | DMSO : 31 mg/mL (80.45 mM) |
| Appearance | powder |
| Color | white to beige |
| pKa | 0.30±0.33(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | ML221 is a potent apelin/APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC 50 s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC 80 of 10 nM in both assays. ML221 is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor (IC 50 , >79 μM) in cells. ML221 displays limited cross reactivity against a range of GPCRs except the κ-opioid and benzodiazepinone receptors (<50/<70%I at 10 μM). |
4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]- - Risk and Safety
| WGK Germany | 3 |
4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.595 ml | 12.975 ml | 25.95 ml |
| 5 mM | 0.519 ml | 2.595 ml | 5.19 ml |
| 10 mM | 0.26 ml | 1.298 ml | 2.595 ml |
| 5 mM | 0.052 ml | 0.26 ml | 0.519 ml |
Last Update：2024-01-02 23:10:35
4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]- - Reference Information
| biological activity | ML221 is an apelin (APJ) antagonist that inhibits apelin-13 of APJ-mediated activation, in the cAMP assay and the β-arrestin assay, the IC50 values were 0.70 μm and 1.75 μm, respectively, and the EC80 value was 10 nM. |
| Target | IC50: 1.75 μm (APJ, cell-based) |
Last Update：2024-04-09 21:32:10
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Spot supply
Product Name: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one Visit Supplier Webpage Request for quotationCAS: 877636-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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